Volume 1 Issue 2
Targeted Homing of Transplanted Human Neural Precursor Cells Tagged with Super Paramagnetic Iron Oxide Nanoparticles for the Treatment of Spinal Cord Injury
Aleem Ahmed Khan*, Sandeep Kumar Vishwakarma, Avinash Bardia, Syed Ameer Basha Paspala, Taimur Athar, J. Venkateshwarlu, Anand Abkari, G.S.N. Murthy
Spinal cord injury is a major devastating condition which leads to significant morbidity and mortality. It causes permanent neurological damage due to injury in motor neurons. Despite enormous developments in medical and surgical cares, the existing clinical treatments for SCI are limited. Exploration of probable utility of stem cells in neurological regeneration and repair has been an exciting development in neuroscience. Despite broad therapeutic benefits, numerous fundamental issues related to stem cell transplantation in SCI remains to be addressed.
Simple Tools for Structuring Embryonic Rudiments
Beloussov LV*, Kremnyov SV, Luchinskaia NN
In this paper we review experimental approaches used in our research group for deforming embryonic tissues in amphibian embryos by relaxing pre-existed tensions, stretching samples in given directions or bending them. In these experiments,owing to the active tissue reactions to changes in mechanical stresses, they change their shapes in predictable ways. In some cases the changes in geometry dictate reconstruction of cell differentiation patterns. We suggest that these results may orient bioengineers in elaborating new technologies permitting to endow artificial organs by required shapes.
Potentiality for a Highly Permissive Micro-Environment in Neurogenesis
Lawrence M Agius*
Reconstitution is the para-developmental series of system pathways as applicable to modulated neurogenesis in the adult human brain and spinal cord. The significance of modulatory induction implicates astrocytes as not only guiding factors in migration of neuroblasts but also as parameters of induced neuroblast proliferation and differentiation. Permissive operants in cell-induced formulas call into play the circulating macrophages and platelets within foci of breakdown of the blood-brain barrier.