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Current Edition

August 2016

Volume 1 Issue 3

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Research Article

High-Power Nd:YAG Laser Triggers Osteogenesis Through BMP-2 and IGF-1 Signaling Pathways In Osteoblasts

Lei Lei*, Jingjing Xu, Jia Yan, Yaoyuan Chen

In the present study, we demonstrated that high-power laser irradiation significantly increased the proliferation of MC3T3-E1 cells. The alkaline phosphatase (ALP) activity of MC3T3-E1 cells was distinctly enhanced after high-power laser irradiation, with an optimal effect observed following treatment for 5 seconds. After the exposure of laser irradiation, MC3T3-E1 cells got a higher level of calcium precipitation. Referring to molecular mechanisms, we found the endogenous gene expression of bone morphogenetic protein-2 (BMP-2) and insulin-like growth factor-1 (IGF-1) was significantly increased by laser irradiation.

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Research Article

Long -Term Activation of Circulating Liver-Committed Mononuclear Cells after OLT

Aleksei N. Shoutko*, Olga A. Gerasimova, Ludmila P. Ekimova, Fiodor K. Zherebtsov, Viktor F. Mus, Dmitry A. Granov, Anatoly M. Granov

Liver viability after orthotopic liver transplantation (OLT) is reportedly dependent on extrahepatic stem cells of host bone marrow origin. Liver-specific proteins were detected in the blood 2 weeks after OLT. We hypothesized that OLT induces longduration recruitment of such cells committed to the graft tissue. Two fractions of cells related to angiogenesis (CD133+ and CD31+) were analyzed by flow cytometry in mononuclear blood cell (MNC) samples from 8 recipients to quantify the alphafetoprotein (AFP)-positive subsets recruited into circulation 2.5–60 months after OLT. The blood of 6 healthy volunteers and 7 patients with cured lung carcinoma (LC) were used as controls to minimize the nonspecific effects of surgery and chemotherapy.

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Review Article

Biodegradable Polymers Composed of Amino Acid Based Diamine-Diesters - Promising Materials for the Applications in Regenerative Medicine

Ramaz Katsarava*, Nina Kulikova, Jordi Puiggalí

A huge family of biodegradable biomaterials could be obtained using key α-amino acid based bis-nucleophilic monomers – diamine-diesters, that comprise both: two hydrolysable ester bonds which contribute to biodegradability of the corresponding polymers with reasonable rates, and two terminal amino groups, which are used for a subsequent chain propagation and provide hydrophilic NH-CO (amide, urethane, and urea) links in the polymeric backbones, promoting tissue compatibility. Regular diamine-diesters on the basis of hydrophobic amino acids along with functional diamine-diesters containing orthogonal protected groups were obtained.

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Research Article

Culture Expansion Increases Lineage Heterogeneity in ELA® Cells: Implications for the Biomanufacturing of Adult Tissue Stem Cell-Based Therapies

Keith D. Crawford*, Baldev Vasir, Shari Benson, Kathryn A. Goldman, Frank Staubli, Jana Sponarova, Farnaz Hadaegh, Thomas S. Thornhill

Previously, we described a population of early lineage adult (ELA®) stem cells isolated from the synovial fluid (SF) of patients with osteoarthritis. These adult stem cells expressed elevated mRNA levels for cardiac-, pancreatic-, and neuronal-specific transcripts. In addition, the ELA® cells were observed to have superior immunosuppressive capabilities to those of mesenchymal stem cells (MSC). The objective of this study was to evaluate the properties of ELA® cells that are relevant to future expansion and biomanufacture for clinical applications.

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Review Article

Regenerative Medicine and Health Technology Assessment: Vision and Challenges

Diana I. Brixner*, Mime Egami, Louis P. Garrison, Bengt Jönsson, Peter J. Neumann,and Isao Kamae

To advance the discussion of regenerative medicine and its future challenges and opportunities, the Third Annual Health Technology Assessment International Symposium and a one-day advisory panel meeting were convened at the University of Tokyo, September 15 -16, 2014, addressing the topic from scientific, economic, and regulatory perspectives. This article presents highlights from that event.

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